Antibiotic Optimization in Today's Hospital Setting: Rethinking Current Treatment Strategies

Post Test, Evaluation and Credit Application Form

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Question Title

1. Among K. pneumoniae isolates in the US, approximately what percent are carbapenem-resistant?

<1%.

5%.

15%.

33%.

Question Title

2. The leading cause of non-urinary tract infections in US hospitals is:

Staphylococcus aureus.

Acinetobacter baumannii.

Haemophilus influenzae.

Staphylococcus epidermidis.

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3. Bacterial mechanisms that confer antimicrobial resistance include all of the following except:

inactivating enzymes that break down the antimicrobial.

altering the target site.

active influx of the antimicrobial into the cell.

blocking entry of the antimicrobial into the cell.

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4. Risk factors for an antimicrobial-resistant infection include all of the following except:

recent prior hospitalization.

nursing home resident.

no recent exposure to an antimicrobial.

hemodialysis.

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5. The most practical method to reduce the spread of resistant bacteria in the hospital is:

improve hand hygiene by healthcare providers.

daily environmental cleaning with sodium hypochlorite solution.

screening and decolonization of all patients and providers.

antimicrobial prophylaxis for all admitted patients.

Question Title

6. Extended infusion of which of the following antimicrobials will have the least benefit to the patient?

Cefepime

Levofloxacin

Piperacillin/tazobactam

Doripenem

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7. The most common serious adverse effect of colistin is:

hepatotoxicity.

nephrotoxicity.

QTc prolongation.

tendon rupture.

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8. When dosing beta-lactams, which of the following will be most effective in increasing the T>MIC?

Decrease the dosing frequency

Increase the dose

Switch from IV to oral agent

Extend the infusion time

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9. Which of the following has the longest half-life?

telavancin

dalbavancin

oritavancin

tedizolid

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10. Which of the following is not a beta-lactamase inhibitor?

tazobactam

avibactam

plazomicin

MK-7655