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Approaches to Target Priority Gram-negative Bacteria: Building a Better Toolbox
Pre-Activity Survey
Pre-Activity Survey
1.
All of the following bacteria were identified by the World Health Organization as critical priority pathogens except:
Methicillin-resistant
S. aureus
Carbapenem-resistant
P. aeruginosa
Carbapenem-resistant
A. baumannii
Carbapenem-resistant, ESBL-producing Enterobacteriaceae
2.
Which of the following carbapenemases is endemic in the United States?
VIM (Verona integrin-encoded)
KPC (
Klebsiella pneumoniae
carbapenemase)
Metallo-beta-lactamase
Oxacillinase
3.
Newer beta-lactam/beta-lactamase inhibitor agents (i.e., ceftolozane-tazobactam, ceftazidime-avibactam) exhibit activity against all of the following resistant organisms except:
ESBL-producing
K. pneumoniae
Fluoroquinolone-resistant
E. coli
Metallo-beta-lactamase-producing
K. pneumoniae
Class A narrow-spectrum beta-lactamases
Multidrug-resistant
P. aeruginosa
4.
The use of rapid diagnostic techniques in clinical microbiology (e.g., MALDI-TOF) is associated with all of the following except:
Earlier time to optimal antimicrobial therapy
More rapid de-escalation of therapy
Decreased hospital length of stay
Increased overall hospitalization costs
5.
Which of the following resistance mechanisms is not typically utilized by
Pseudomonas aeruginosa
?
Overexpression of drug efflux pumps
Beta-lactamase upregulation
Mutations in reverse transcriptase enzyme
Penicillin-binding protein alterations
6.
Which of the following emerging agents is a siderophore cephalosporin that exhibits in vitro activity against
Acinetobacter baumannii
?
Relebactam
Cefiderocol
Zidebactam
Plazomicin