MSI Market Survey 2023 (Non-Idylla™)

Thank you for agreeing to complete our MSI Market Research survey on MSI testing.

The survey questionnaire will take approximately 5-10 minutes to complete. Your honest feedback is highly appreciated since it is essential input for further optimization of our Biocartis products and services.

All gathered information will be treated confidential and will not be shared outside Biocartis.

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* 1. Contact information

Name *

Function *

Institute *

City/Town

Country *

Email Address

Phone Number

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* 2. Indicate below in which cancer types you test for IHC MMR and/or Molecular MSI

Colorectal Cancer

Endometrial Cancer

Gastric Cancer

Rectal Cancer

In case of other cancer type(s), please specify

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* 3. For which indication do you test for IHC MMR/Molecular MSI?

	Colorectal Cancer	Endometrial Cancer	Gastric Cancer
Lynch Syndrome	Lynch Syndrome Colorectal Cancer	Lynch Syndrome Endometrial Cancer	Lynch Syndrome Gastric Cancer
Immunotherapy	Immunotherapy Colorectal Cancer	Immunotherapy Endometrial Cancer	Immunotherapy Gastric Cancer
Information not available	Information not available Colorectal Cancer	Information not available Endometrial Cancer	Information not available Gastric Cancer

If applicable, please specify other cancer type(s) & indication(s)

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* 4. Do you perform: (1 answer per cancer type)

	Colorectal Cancer	Endometrial Cancer	Gastric Cancer
Parallel testing: IHC MMR and molecular MSI together	Parallel testing: IHC MMR and molecular MSI together Colorectal Cancer	Parallel testing: IHC MMR and molecular MSI together Endometrial Cancer	Parallel testing: IHC MMR and molecular MSI together Gastric Cancer
Reflex testing: 1 method first, followed by a 2nd method	Reflex testing: 1 method first, followed by a 2nd method Colorectal Cancer	Reflex testing: 1 method first, followed by a 2nd method Endometrial Cancer	Reflex testing: 1 method first, followed by a 2nd method Gastric Cancer
Single testing: 1 method only	Single testing: 1 method only Colorectal Cancer	Single testing: 1 method only Endometrial Cancer	Single testing: 1 method only Gastric Cancer

If applicable, please specify other cancer type(s) & type(s) of testing

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* 5. In case of parallel testing, what is the main reason?

	Colorectal Cancer	Endometrial Cancer	Gastric Cancer
According to the European ESMO guidelines for immuno-oncology (here)	According to the European ESMO guidelines for immuno-oncology (here) Colorectal Cancer	According to the European ESMO guidelines for immuno-oncology (here) Endometrial Cancer	According to the European ESMO guidelines for immuno-oncology (here) Gastric Cancer
According to your local guidelines	According to your local guidelines Colorectal Cancer	According to your local guidelines Endometrial Cancer	According to your local guidelines Gastric Cancer
Other (please specify below)	Other (please specify below) Colorectal Cancer	Other (please specify below) Endometrial Cancer	Other (please specify below) Gastric Cancer

Please specify

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* 6. In case of reflex testing, what is the 1st line method you use?

	Colorectal Cancer	Endometrial Cancer	Gastric Cancer
IHC - IHC MMR	IHC - IHC MMR Colorectal Cancer	IHC - IHC MMR Endometrial Cancer	IHC - IHC MMR Gastric Cancer
Molecular MSI - Lab developed method	Molecular MSI - Lab developed method Colorectal Cancer	Molecular MSI - Lab developed method Endometrial Cancer	Molecular MSI - Lab developed method Gastric Cancer
Molecular MSI - Promega	Molecular MSI - Promega Colorectal Cancer	Molecular MSI - Promega Endometrial Cancer	Molecular MSI - Promega Gastric Cancer
Molecular MSI - Idylla™	Molecular MSI - Idylla™ Colorectal Cancer	Molecular MSI - Idylla™ Endometrial Cancer	Molecular MSI - Idylla™ Gastric Cancer
Molecular MSI - Other commercial method (please specify in the comments box below)	Molecular MSI - Other commercial method (please specify in the comments box below) Colorectal Cancer	Molecular MSI - Other commercial method (please specify in the comments box below) Endometrial Cancer	Molecular MSI - Other commercial method (please specify in the comments box below) Gastric Cancer
Molecular MSI - NGS	Molecular MSI - NGS Colorectal Cancer	Molecular MSI - NGS Endometrial Cancer	Molecular MSI - NGS Gastric Cancer
Not applicable	Not applicable Colorectal Cancer	Not applicable Endometrial Cancer	Not applicable Gastric Cancer

If applicable, please specify other cancer type(s) & method(s)

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* 7. In case of reflex testing, what is the 2nd line method you use?

	Colorectal Cancer	Endometrial Cancer	Gastric Cancer
IHC - IHC MMR	IHC - IHC MMR Colorectal Cancer	IHC - IHC MMR Endometrial Cancer	IHC - IHC MMR Gastric Cancer
Molecular MSI - Lab developed method	Molecular MSI - Lab developed method Colorectal Cancer	Molecular MSI - Lab developed method Endometrial Cancer	Molecular MSI - Lab developed method Gastric Cancer
Molecular MSI - Promega	Molecular MSI - Promega Colorectal Cancer	Molecular MSI - Promega Endometrial Cancer	Molecular MSI - Promega Gastric Cancer
Molecular MSI - Idylla™	Molecular MSI - Idylla™ Colorectal Cancer	Molecular MSI - Idylla™ Endometrial Cancer	Molecular MSI - Idylla™ Gastric Cancer
Molecular MSI - Other commercial method (please specify in the comments box below)	Molecular MSI - Other commercial method (please specify in the comments box below) Colorectal Cancer	Molecular MSI - Other commercial method (please specify in the comments box below) Endometrial Cancer	Molecular MSI - Other commercial method (please specify in the comments box below) Gastric Cancer
Molecular MSI - NGS	Molecular MSI - NGS Colorectal Cancer	Molecular MSI - NGS Endometrial Cancer	Molecular MSI - NGS Gastric Cancer
Not applicable	Not applicable Colorectal Cancer	Not applicable Endometrial Cancer	Not applicable Gastric Cancer

If applicable, please specify other cancer type(s) & method(s)

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* 8. What is your average IHC MMR turnaround time, from test request to result reporting? (one answer per cancer type)

	Colorectal Cancer	Endometrial Cancer	Gastric Cancer
<24h	<24h Colorectal Cancer	<24h Endometrial Cancer	<24h Gastric Cancer
24h - 48h	24h - 48h Colorectal Cancer	24h - 48h Endometrial Cancer	24h - 48h Gastric Cancer
48h - 72h	48h - 72h Colorectal Cancer	48h - 72h Endometrial Cancer	48h - 72h Gastric Cancer
>72h	>72h Colorectal Cancer	>72h Endometrial Cancer	>72h Gastric Cancer
Not applicable	Not applicable Colorectal Cancer	Not applicable Endometrial Cancer	Not applicable Gastric Cancer

If applicable, please specify other cancer type(s)

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* 9. To which External Quality Assessment do you participate for any of the methods that you use? Please specify

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* 10. What is the % equivocal IHC MMR staining? (one answer per cancer type)

	Colorectal Cancer	Endometrial Cancer	Gastric Cancer
<5%	<5% Colorectal Cancer	<5% Endometrial Cancer	<5% Gastric Cancer
5-10%	5-10% Colorectal Cancer	5-10% Endometrial Cancer	5-10% Gastric Cancer
10-20%	10-20% Colorectal Cancer	10-20% Endometrial Cancer	10-20% Gastric Cancer
>20%	>20% Colorectal Cancer	>20% Endometrial Cancer	>20% Gastric Cancer

If applicable, please specify for other cancer type(s)

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* 11. In case of MSI testing in endometrial cancer, what is the % neoplastic cell content used as input?

	Endometrial Cancer
<20%	<20% Endometrial Cancer
20-30%	20-30% Endometrial Cancer
30-40%	30-40% Endometrial Cancer
>40%	>40% Endometrial Cancer
Information not available	Information not available Endometrial Cancer

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* 12. What is the average cost per IHC MMR antibody?

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* 13. What is your estimated annual IHC MMR volume?

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* 14. What is your estimated annual molecular MSI volume?

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* 15. Thanks for taking part, that’s all we had to ask you today. As a token of our appreciation, we would like to send you a small gift. Please enter your full name and address below:

Name

Address

Address 2

City/Town

State/Province

ZIP/Postal Code

Country

Phone Number

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* 16. Please choose your preferred gift from one of the options below

Octopus charger

Notebook + pen

3 Post-it booklets

I don’t wish to receive a gift