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A840 POST SURVEY & EVAL - Know-It-When-You-See-It: Diagnosis and Initial Treatment of Oral Pemphigus Vulgaris

Know-It-When-You-See-It: Diagnosis and Initial Treatment of Oral Pemphigus Vulgaris
POSTTEST and EVALUATION

Question Title

* 1. Which of the following symptoms is consistent with oral pemphigus vulgaris?

a. Oral white patches

b. Oral flaccid blisters and ulcers

c. Small white keratinized oral plaques

d. Self-limited scarring oral blisters

Question Title

* 2. Which of the following tests can be used to confirm a diagnosis of pemphigus vulgaris?

a. ELISA for anti-keratin antibodies

b. Nikolsky’s sign

c. Epidermal IgG deposits by direct immunofluorescence

d. Physical presentation

Question Title

* 3. A 36-year-old man presents to you with oral lesions suggestive of pemphigus vulgaris. Which of the following would confirm the diagnosis of PV?

a. Biopsy with both H and E staining showing acantholysis and direct immunofluorescence showing intercellular IgG

b. Biopsy with H and E staining showing epidermal denudation and ELISPOT showing desmoglein-specific B cells

c. Positive ELISA for anti-desmoglein 1 and 3 antibodies

d. Positive Indirect immunofluorescence for circulating IgG antibodies

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* 4. Which of the following was observed in patients with pemphigus vulgaris treated with the combination of rituximab and prednisone in the phase 3 RITUX 3 trial?

a. 24-month disease-free survival of 50%

b. 1 patient death due to rituximab-related toxicity

c. 36% improvement in disease-free survival compared to prednisone alone

d. 24-month remission rate of 89%

Question Title

* 5. A 42-year-old woman presents with diagnosed pemphigus vulgaris. Based on current guidelines, what treatment approach would you recommend?

a. Topical corticosteroids

b. Rituximab plus prednisone

c. Cyclophosphamide plus prednisone

d. Prednisone monotherapy

Question Title

* 6. After participating in this activity, how confident are you now in your ability to:

	1-Not at all confident	2-Somewhat confident	3-Confident	4-Very confident
Diagnose oral PV based on presenting symptoms and appropriate testing	Diagnose oral PV based on presenting symptoms and appropriate testing 1-Not at all confident	Diagnose oral PV based on presenting symptoms and appropriate testing 2-Somewhat confident	Diagnose oral PV based on presenting symptoms and appropriate testing 3-Confident	Diagnose oral PV based on presenting symptoms and appropriate testing 4-Very confident
Outline initial and long-term treatment plans for patients with oral PV	Outline initial and long-term treatment plans for patients with oral PV 1-Not at all confident	Outline initial and long-term treatment plans for patients with oral PV 2-Somewhat confident	Outline initial and long-term treatment plans for patients with oral PV 3-Confident	Outline initial and long-term treatment plans for patients with oral PV 4-Very confident

Question Title

* 1. Which of the following symptoms is consistent with oral pemphigus vulgaris?

Question Title

* 2. Which of the following tests can be used to confirm a diagnosis of pemphigus vulgaris?

Question Title

* 3. A 36-year-old man presents to you with oral lesions suggestive of pemphigus vulgaris. Which of the following would confirm the diagnosis of PV?

Question Title

* 4. Which of the following was observed in patients with pemphigus vulgaris treated with the combination of rituximab and prednisone in the phase 3 RITUX 3 trial?

Question Title

* 5. A 42-year-old woman presents with diagnosed pemphigus vulgaris. Based on current guidelines, what treatment approach would you recommend?

Question Title

* 6. After participating in this activity, how confident are you now in your ability to:

Question Title

* 7. Please indicate the meeting you attended: