Question 1 Question Title * 1. What is the molecular mechanism involved in the RYR2 gene mutation? A. Raising the magnitude of cell-averaged ICA-induced calcium transients and spontaneous calcium sparks in isolated heart cells. B. Reducing RyR2 channel activity during adrenergic stimulation (eg, simulated exercise, beta adrenergic stimulation) causing an increased diastolic calcium release and arrhythmic burden. C. Increasing RyR2 channel activity during adrenergic stimulation (eg, simulated exercise, beta adrenergic stimulation) causing an increased diastolic calcium release and arrhythmic burden. D. Stabilising FK506 protein preventing aberrant activation. E. Reducing intracellular calcium levels stimulating SERCA2 channel protein. 4% of survey complete. Next