Quiz: Emerging Therapies for Breast Cancer

Welcome! Please note that the quiz consists of just 9 short questions. If you win a prize, we will use the contact information you provide on this page to get in touch. Good luck and thank you for supporting our cause!

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* 1. Breast cancer is the most commonly diagnosed and second leading cause of cancer-related deaths in women globally.

True

False

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* 2. Several types of breast cancer include Ductal Carcinoma In Situ, Invasive Lobular Carcinoma, and Triple-negative Breast Cancer.

True

False

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* 3. Triple-negative breast Cancer is difficult to treat because of the absence of receptors for:

Estrogen and Progesterone

Estrogen, Progesterone, and HER2

Estrogen and HER2

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* 4. Emerging therapies for breast cancer include the following modalities:

Antibody-based and antibody-drug conjugate therapies

Gene and cell therapies and vaccines

All of the above

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* 5. Therapeutic antibodies fight breast cancer through different mechanisms. In Antibody-dependent-cell-cytotoxicity (ADCC)-

Antibody bound to the tumor antigen is recognized by natural killer (NK) cells triggering cytotoxic activity

Antibody bound to the tumor antigen opsonizes the cell and activates phagocytic cells

Antibodies can trigger direct apoptosis after binding to an antigen on the tumor cell surface

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* 6. The following is true about ENHERTU®, developed by Daiichi Sankyo and AstraZeneca:

An antibody-drug conjugate of trastuzumab and deruxtecan

Approved in 2024 to treat patients with HER2-positive metastatic breast cancer

All of the above

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* 7. Gene and cell therapies for breast cancer are undergoing early clinical studies leveraging:

ex vivo engineering of T cells

in vivo delivery of therapeutic genes

All of the above

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* 8. Several CAR-T cells undergoing clinical evaluation target the following tumor antigens

HER-2, MUC1

MUC1, BRCA

HER-2, CEA

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* 9. Cancer vaccines can be both therapeutic and prophylactic

True

False