Identifying Researcher Needs in Pre-Clinical FUS Equipment Question Title * 1. How do you best identify yourself? Researcher Physician Scientist Physicist Other OK Question Title * 2. What is your level of experience with FUS? < 1 years 1 – 5 years 5 – 10 years > 10 years OK Question Title * 3. What modality are you interested in? Check all that apply Thermal ablation Mechanical effects (ablative, ie histotripsy, etc) Mechanical effects (non-ablative ie, BBB opening, etc) Hyperthermia Other (please specify) OK Question Title * 4. Thinking back to when you first worked with FUS, please rate your proficiency in the following areas: [1 = never used, 5 = expert] Never Used 2 3 4 Expert FUS Ultrasound Physics FUS Ultrasound Physics Never Used FUS Ultrasound Physics 2 FUS Ultrasound Physics 3 FUS Ultrasound Physics 4 FUS Ultrasound Physics Expert FUS Electronics FUS Electronics Never Used FUS Electronics 2 FUS Electronics 3 FUS Electronics 4 FUS Electronics Expert FUS Biological Effects FUS Biological Effects Never Used FUS Biological Effects 2 FUS Biological Effects 3 FUS Biological Effects 4 FUS Biological Effects Expert FUS Clinical Application FUS Clinical Application Never Used FUS Clinical Application 2 FUS Clinical Application 3 FUS Clinical Application 4 FUS Clinical Application Expert OK Question Title * 5. Please rate your current proficiency in the following areas: Never Used 2 3 4 Expert FUS Ultrasound Physics FUS Ultrasound Physics Never Used FUS Ultrasound Physics 2 FUS Ultrasound Physics 3 FUS Ultrasound Physics 4 FUS Ultrasound Physics Expert FUS Electronics FUS Electronics Never Used FUS Electronics 2 FUS Electronics 3 FUS Electronics 4 FUS Electronics Expert FUS Biological Effects FUS Biological Effects Never Used FUS Biological Effects 2 FUS Biological Effects 3 FUS Biological Effects 4 FUS Biological Effects Expert FUS Clinical Application FUS Clinical Application Never Used FUS Clinical Application 2 FUS Clinical Application 3 FUS Clinical Application 4 FUS Clinical Application Expert OK Question Title * 6. What are you currently treating? Check all that apply. Cells, tissues or phantoms Small animals (mice, rats, rabbits) Large animals (dog, monkey, pig) Humans Other (please specify) OK Question Title * 7. If working in animals, which body system are you treating? Check all that apply. Cardiovascular Endocrine Disorders Gastrointestinal Musculoskeletal Neurological Oncological Ophthalmological Pain Pediatrics Pulmonary Urological Women's Health Other (please specify) OK Question Title * 8. What HIFU frequency range(s) are you interested in? Check all that apply. <500kHz 500kHz-1 MHz 1-3 MHz 3-10 MHz >10 MHz OK Question Title * 9. What is the volume of tissue you are interested in treating? <50mm3 50mm3 – 0.5cm3 0.5cm3 – 3.0cm3 >3.0cm3 OK Question Title * 10. Which ultrasound coupling mechanisms do you utilize during experiments? Check all that apply. Immersion tank Coupling cone Water bag Ultrasound gel Hydrogel standoff Other (please specify) OK Question Title * 11. What ultrasound transducer positioning systems (independent of electronic steering) do you utilize during experiments? Check all that apply. Handheld Mechanically assisted (robotic arm, 3D axis motors, etc) Fixed Other (please specify) OK Question Title * 12. Thinking back to when you first worked with FUS, what ultrasound-related equipment did you have access to? Check all that apply. Field mapping capability (hydrophone + motion stage + tank) Radiation force balance Oscilloscope Impedance analyzer Other (please specify) OK Question Title * 13. What ultrasound-related equipment do you currently have access to? Check all that apply. Field mapping capability (hydrophone + motion stage + tank) Radiation force balance Oscilloscope Impedance analyzer Other (please specify) OK Question Title * 14. What methods do you use to verify that you are treating the correct target? Check all that apply. Thermochromic phantom Tissue-mimicking phantom Real-time monitoring (MR thermometry, thermocouple, cavitation localization, etc) Animal/tissue restraint system Other (please specify) OK Question Title * 15. What guidance system do you use for targeting? MR Ultrasound Optical / microscopic Neuronavigation Other (please specify) OK Question Title * 16. Do you anticipate purchasing a commercial FUS system or transducer in the near future? No Yes. Please tell us what lead to this decision. OK Question Title * 17. When you previously purchased new FUS equipment, what were you most concerned about? Check all that apply: Turnkey FUS system (all components included) Relevance to clinical translation Budgetary constraints Customization. Please tell us what type of customization you were interested in and why. OK Question Title * 18. Thinking back to when you were planning your lab set-up, which of the following resources did you utilize? Please check all that apply Manufacturer Research paper Colleagues Other (please specify) OK Question Title * 19. If you were to set-up a lab today, which of the following resources would you utilize? Manufacturer Research paper Colleagues Other (please specify) OK Question Title * 20. Which of the following budget ranges best represents your lab’s fiscal constraints for purchasing a new FUS system? <$30k $30k - $150k $150k –$300k >$300k OK Question Title * 21. What is the first item that you would choose when designing a new FUS system? Transducer Power amplifier Function generator Not applicable – purchase turn-key preclinical systems Not applicable – purchase clinical systems No preference OK Question Title * 22. What is the biggest obstacle that you face when designing or ordering a new FUS system: Product lead time Budget Product support (understanding what you need) OK Question Title * 23. In your experience, what is the most rate-limiting issue between project conception and publication? Access to equipment Data processing Intrinsic experimental design (long term survival, etc) Unexpected experimental problems Other (please specify) OK Question Title * 24. Please select the level of ultrasound engineering staff that your lab has access to; check all that apply: Biological/medical only Some programming skills Mechanical engineering (fixtures, holders, etc) Electronics design MRI or diagnostic US (for guidance) Bioengineering or sonography experience Advanced ultrasound physics and programming skills OK Question Title * 25. Do you or your team need training? If so, please rank the following training methodologies from preferred to least preferred. 1 = most preferred 4 = least preferred 1 2 3 4 FUS lab set-up guide 1 2 3 4 Learning Management System training (training portal online) 1 2 3 4 Webinar 1 2 3 4 Application consultant – two weeks of on-site time. OK Question Title * 26. When you first entered the field of FUS what would have been the most beneficial to you for improving lab start-up time: FUS lab set-up guide Learning Management System training (training portal online) Webinar Application consultant OK Question Title * 27. In your experience, what has been the most problematic component of your FUS system? Transducer Amplifier Signal generator Connectors/cables Coupling to target OK Question Title * 28. Please provide more details OK Question Title * 29. Are there any additions, changes or improvements that you would like to recommend to the FUS manufacturing community? ie increase power capabilities, improve the mechanical robustness, increase durability, reduce delivery times/cost, etc. Please comment. OK Question Title * 30. Would you be willing to participate in a focus group to provide further input to this topic? No Yes. Please provide your name and email below. OK DONE