BologniaQuiz21 Question Title * 1. Name Question Title Question Title * 2. Based on the above histology results from a lesion on a patient’s chest, a blood test was ordered to check for increased circulating levels of which of the following: A. Lactate Dehydrogenase B. Tryptase C. VEGF D. Creatinine Kinase E. Type 3 iodothyronine deiodinase Question Title Question Title * 3. The above patient was found to have a deficiency in which of the following lysosomal enzymes A. Iduronate Sulfatase B. Beta-glucosidase C. Alpha-galactosidase A D. α-L-iduronidase Question Title Question Title * 4. A biopsy of this lesion showed proliferating capillaries grouped into lobules by dense fibrous bands. Which of the following is the diagnosis? A. Granular Cell Tumor B. Masson’s lesion C. Glomeruloid hemangioma D. Angiolymphoid hyperplasia E. Tufted angioma F. Granuloma gravidarum G. Hobnail hemangioma Question Title Question Title * 5. The above histology is from a lesion on an infant’s upper trunk . This lesion can be associated with which of the following? A. Beckwith-Wiedemann Syndrome B. Cowden Syndrome C. CHILD Syndrome D. Birt-Hogg-Dube Syndrome E. Kasabach-Merritt Syndrome Question Title Question Title * 6. One of the above lesions was biopsied, what would you expect to see on biopsy A. Canalized cords and nests of endothelial cells in a myxoid background B. Rosette-like intravascular clusters of hobnailed, columnar endothelial cells. C. Cannonball distribution of dense capillary lobules D. Slit-like spaces containing erythrocytes Question Title Question Title * 7. The above patient is a 67-year-old woman with a history of cancer of the right breast, treated with a modified radical mastectomy, radiation, and chemotherapy in 1990, presented with a 6-month history of an enlarging plaque of coalescing purple papules and nodules within a region of chronic lymphedema of the right upper arm. Which of the following two stains would you expect to be positive for the tissue biopsied? A. S100 and HMB-45 B. CD31 and CD34 C. Vimentin and Smooth Muscle Actin D. CK 20 and TTF-1 Question Title Question Title * 8. Which of the following would you most likely recommend to the above patient after a biopsy of one of the lesions showed a palisaded encapsulated neuroma (best answer)? A. Reassurance B. Watchful Waiting C. Prophylactic thyroidectomy after confirmatory genetic testing D. Chemotherapy/Radiation Question Title Question Title * 9. This patient had pain when you pressed the above fingernail and said the finger hurts when she washes her hands with cold water. An MRI of the lesion showed a strongly enhancing mass. Which of the following is the likely diagnosis? A. Onychomatricoma B. Myxoid Cyst C. Subungual Exostosis D. Glomus Tumor Question Title Question Title * 10. Which of the following lesions (pictured above) is considered pathognomonic for neurofibromatosis type 1? A. Neurilemmoma B. Cellular Neurothekeoma C. Traumatic Neuroma D. Ancient Schwannoma E. Plexiform Neurofibroma Question Title Question Title * 11. The above lesion was originally diagnosed as a squamous cell carcinoma of the tongue. Upon review of the diagnosis, which of the following stains would you expect to be positive for the correct diagnosis but not positive for a squamous cell carcinoma? A. HMB-45 B. Cytokeratin C. Smooth Muscle Actin D. S100 Question Title Question Title * 12. This lesion was biopsied and stained positive for CK20. Which of the following stains should you order to differentiate the lesion from a metastasis of lung carcinoma? A. Polyomavirus B. Ulex europeans agglutinin 1 C. Factor VIII-related antigen D. S100 E. Thyroid transcription factor 1 Question Title Question Title * 13. Which is the next best step of management for this lesion in a newborn? A. Reassurance B. Biopsy C. Imaging-Ultrasound/MRI D. Watchful waiting Done