Post-Activity Test and Activity Evaluation POST TEST Question Title * 1. Which of the following is the most common carbapenemase identified in the United States? K. pneumoniae carbapenemase (KPC) New Delhi metallo-beta-lactamase (NDM) Verona integrin-encoded (VIM) Imipenemase (IMP) Question Title * 2. Carbapenem resistance by P. aeruginosa in the US is most frequently associated with: NDM carbapenemase OXA-48-type carbapenemase VIM carbapenemase A non-carbapenemase-producing mechanism Question Title * 3. Pneumonia that occurs at least 48 hours after initiating mechanical ventilation is called: Severe CAP HAP Ventilated HAP VAP Question Title * 4. The most common pathogens for HAP/VAP include all of the following except: S. aureus S. pneumoniae P. aeruginosa K. pneumoniae Question Title * 5. Newer beta-lactamase inhibitors (e.g., avibactam, vaborbactam) are effective against all of the following beta-lactamases except: ESBLs Class A carbapenemases (e.g., KPCs) Class B metallo-beta-lactamases ampC beta-lactamases Question Title * 6. Which of the following agents exhibits the greatest in vitro activity against MDR P. aeruginosa? Delafloxacin Ceftolozane-tazobactam Ceftazidime-avibactam Eravacycline Question Title * 7. The REPROVE trial that compared ceftazidime-avibactam versus meropenem for nosocomial pneumonia demonstrated all of the following except: Similar clinical cure rates in the overall patient population Similar clinical cure rates among patients with VAP Superiority of ceftazidime-avibactam over meropenem in clinical cure rates against infections caused by P. aeruginosa Similar clinical cure rates among patients with infections caused by K. pneumoniae Question Title * 8. All of the following are correct regarding the ASPECT-NP trial comparing ceftolozane-tazobactam against meropenem for nosocomial pneumonia EXCEPT? P. aeruginosa comprised approximately 25% of the pathogens identified Approximately one-third of participants were ventilated Overall 28-day all-cause mortality rates were similar between treatment groups Overall clinical cure rates were similar between treatment groups Next