Perioperative antimicrobial prophylaxis strategies in pediatric liver transplantation: an intentional survey by IPTA's ID group. |
This 15 minute survey created by IPTA’s IDCARE committee aims to understand the current prophylaxis strategies for pediatric liver transplantation employed around the world.
Definitions
Perioperative prophylaxis: administration of antibiotic and/or antifungal medications in the time surrounding (prior, during, and post) liver transplantation with the goal of reducing postoperative infection risk.
MDRO: multidrug resistant organism: defined as microorganisms, predominately bacteria that are resistant to one or more classes of antimicrobial agents.
Extended-spectrum beta-lactamase (ESBL) producing Enterobacterales: ESBLs are enzymes that mediate resistance to extended-spectrum (third generation) cephalosporins (e.g., ceftazidime, cefotaxime, and ceftriaxone) and monobactums (e.g. aztreonam) but do not affect cephamycins (e.g. cefoxitin and cefotetan) or carbapenems (e.g., meropenem or impenem).
Carbapenem-resistant Enterobacterales (CRE): defined as Enterobacterales resistant to carbapenems (resistant to meropenem, ertapenem, or imipenem).
Methicillin-resistant S. aureus (MRSA): defined as Staphylococcus aureus resistant to oxacillin.
Vancomycin resistant enterococcus (VRE): defined as Enterococcus sp. resistant to vancomycin.